After intermittent treatment with busulphan over a 7-year period for chronic myeloid leukemia (CML) in chronic phase, a 39-year-old female developed leukocytosis in association with pure red cell aplasia (PRCA). Bone marrow examination confirmed erythroid aplasia, and culture revealed a total absenc
Sequential pure red cell and megakaryocyte aplasia associated with chronic liver disease and ulcerative colitis
โ Scribed by Dr Richard M. Fox; Dr Frank C. Firkin
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 464 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
The clinical course of a patient with chronic hepatitis and previous ulcerative colitis who subsequently developed pure red cell aplasia (PRCA) is described. The PRCA remitted initially with corticosteroid therapy. A subsequent relapse responded to cyclophosphamide therapy following splenectomy. This was followed by a fatal third episode of red cell aplasia associated with megakarocyte aplasia.
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