After intermittent treatment with busulphan over a 7-year period for chronic myeloid leukemia (CML) in chronic phase, a 39-year-old female developed leukocytosis in association with pure red cell aplasia (PRCA). Bone marrow examination confirmed erythroid aplasia, and culture revealed a total absenc
Pure red cell aplasia as possible early manifestation of chronic myeloid leukemia
✍ Scribed by Dr. Oskar A. Haas; Wolfgang Hinterberger; Reinhard Mörz
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 498 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0361-8609
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A 40-year-old woman presented with splenomegaly, macrocytic anemia, and red cell aplasia. Although lymphocytosis was absent in the peripheral blood, large atypical lymphoid aggregates were present in the bone marrow. Splenectomy resulted in partial remission of red cell aplasia, but a gradual increa
Pure red cell aplasia (PRCA) is an unusual complication of chronic lymphoproliferative disorders. A patient with T-cell chronic lymphocytic leukemia (T-CLL) had severe anemia and neutropenia. Initial in vitro studies demonstrated no evidence of T-cell suppression of erythropoiesis. Sequential bone m