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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
β Scribed by Kass, David A; Takimoto, Eiki; Champion, Hunter C; Li, Manxiang; Belardi, Diego; Ren, Shuxun; Rodriguez, E Rene; Bedja, Djahida; Gabrielson, Kathleen L; Wang, Yibin
- Book ID
- 109932075
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 799 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/nm1175
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Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime.
Phosphodiesterase 5 (PDE5) is a major isoform of cGMP phosphodiesterase in a variety of human tumor cell lines and plays a key role in regulating intracellular cGMP concentrations ([cGMP]i). Here, we demonstrate that suppression of PDE5 gene expression by antisense pZeoSV2/ASP5 plasmid transfection