Effect of atrial natriuretic peptide and cyclic GMP phosphodiesterase inhibition on collagen synthesis by adult cardiac fibroblasts

STIMULATION OF COLLAGEN SYNTHESIS IN RAT

STIMULATION OF COLLAGEN SYNTHESIS IN RAT CARDIAC FIBROBLASTS BY EXPOSURE TO HYPOXIC CULTURE CONDITIONS AND SUPPRESSION OF THE EFFECT BY NATRIURETIC PEPTIDES

✍ MIMI TAMAMORI; HIROSHI ITO; MICHIAKI HIROE; FUMIAKI MARUMO; RYU-ICHIRO HATA 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 392 KB

Synthesis of type I and type III collagens by rat cardiac fibroblasts was stimulated when the cells were cultured under 95% N 2 /5% CO 2 for one hour followed by incubation under normoxic conditions for 24 hours. The stimulative effect was attenutated by the presence of atrial natriuretic peptide (A