Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: Differential subcellular localization and regulated expression by cyclic AMP

Induction of cyclic AMP synthesis by for

Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c-myc messenger RNA and inhibition of 3H-thymidine incorporation in human fibroblasts

✍ Nils-Erik Heldin; Ylva Paulsson; Karin Forsberg; Carl-Henrik Heldin; Bengt Weste 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 785 KB

We have studied the effect of increased intracellular levels of cyclic AMP on the growth response to platelet-derived growth factor (PDGF) of human foreskin fibroblasts in culture. It was found that forskolin, a potent stimulator of adenylate cyclase activity, inhibits the stimulatory effect of PDGF