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Chromosome analysis of 73 thyroid neoplasms

✍ Scribed by Lucia Roque; Paula Gomes; Cecilia Correia; Paula Soares; Carmo Martins; Sergio Castedo; Jorge Soares

Book ID
113253516
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
93 KB
Volume
77
Category
Article
ISSN
0165-4608

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## Abstract The underlying genetic events associated with follicular thyroid tumorigenesis are still ill defined. In this study, we performed a screening for chromosome imbalances by comparative genomic hybridization (CGH) in a group of 12 follicular adenomas (FAs) and 20 follicular carcinomas (FTC

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Short-term cultures of 19 follicular thyroid carcinomas were examined cytogenetically. Clonal chromosomal changes were detected in 12 tumors. Two follicular carcinomas had only numerical alterations: one with a hyperdiploid karyotype with trisomies/polysomies of chromosomes 7 and 12, similar to the