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Follicular thyroid carcinoma: Chromosome analysis of 19 cases

✍ Scribed by Lúcia Roque; Ana Clode; Gazanfer Belge; António Pinto; Sabine Bartnitzke; Jorge Rosa Santos; Brita Thode; Jörn Bullerdiek; Sérgio Castedo; Jorge Soares

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
144 KB
Volume
21
Category
Article
ISSN
1045-2257

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✦ Synopsis

Short-term cultures of 19 follicular thyroid carcinomas were examined cytogenetically. Clonal chromosomal changes were detected in 12 tumors. Two follicular carcinomas had only numerical alterations: one with a hyperdiploid karyotype with trisomies/polysomies of chromosomes 7 and 12, similar to the karyotypes previously identified in a sub-group of benign thyroid lesions, and the other with monosomy 20. In the remaining ten cases several structural chromosome anomalies were found. Loss of the short arm of chromosome 3 was observed in one tumor. In two widely invasive and metastasizing follicular carcinomas there was a t(7;8)(p15;q24) as the sole abnormality in one case and a der(8)t(7;8)(p15;q24) together with other cytogenetic alterations in the other case. This finding suggests that t(7;8)(p15;q24) may be related to an aggressive behavior of follicular thyroid carcinomas.

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