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Chromosome 10 allelic loss in malignant melanoma

✍ Scribed by Koichi Isshiki; David E. Elder; Dupont Guerry; Dr. Alban J. Linnenbach

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 602 KB
Volume: 8
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870080307

No coin nor oath required. For personal study only.

✦ Synopsis

The involvement of tumor suppressor genes in the progression of melanoma has been suggested by the frequent deletion of specific regions of the genome in melanoma. In this study, a panel of I 8 surgically removed melanomas from I 5 patients was analyzed for loss of heterozygosity (LOH) at I0 polymorphic loci on chromosome 10. LOH was observed in 7 (50%) of I4 informative patients. LOH data suggested that melanomas from 5 patients had lost entire copies of chromosome 10, and that melanomas from 2 patients had lost copies of I Oq. In contrast, LOH was not observed on chromosome 15, 20, or 2 I. These results are consistent with previous cytogenetic observations and provide indirect evidence that there is a tumor suppressor gene on the long arm of chromosome 10 which is relevant to melanoma development. Genes Chrom Cancer 8:/78-184 (1993).

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