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Allelic losses in human chromosome II in lung cancers

✍ Scribed by Masayoshi Lizuka; Yuki Sugiyama; Masahiko Shiraishi; Carol Jones; Dr. Takao Sekiya

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 524 KB
Volume: 13
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870130107

No coin nor oath required. For personal study only.

✦ Synopsis

The relatively frequent loss of heterozygosity at loci on the short arm of chromosome I I in human lung cancers has suggested the presence of a putative tumor suppressor gene. For location of the gene, a fine deletion map of human chromosome I I was constructed by analysis of DNAs from 79 lung cancers with 3 I sequence-tagged-site markers that dotted chromosome I I and detected polymorphic changes in nucleotide sequences. The results showed that three regions, I I p 12-p IS, I I q 12, and I I q I4-q24, were commonly deleted in a considerable number of cancers, indicating the possible presence of more than one tumor suppressor gene. The range of deletion in the I I p I 5 region was estimated to be 4.5 megabases. That in the I I q24-q24 region was divided into two portions: one was 3 cM in length, and the other was longer and could not be specified because of lack of appropriate markers. The deletion in the I I q I 2 region was so short that two markers flanking the region could not be identified by genetic analysis. Genes Chrornosorn Cancer 13:40-46 (1995).

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