Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation
✍ Scribed by Anatoly A. Philimonenko; Jiri Janacek; Luc Snyers; Marlene Almeder; Walter Berger; Wolfgang Schmidt; Christian Schöfer; Pavel Hozák; Klara Weipoltshammer
- Book ID
- 116697136
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 987 KB
- Volume
- 173
- Category
- Article
- ISSN
- 1047-8477
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## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th
## Abstract Cell cycle progression beyond the G~1~/S phase transition requires the activation of a transcription complex containing histone nuclear factor P (HiNF‐P) and nuclear protein mapped to ataxia telangiectasia (p220^NPAT^) in response to cyclin dependent kinase 2 (CDK2)/cyclin E signaling.