𝔖 Bobbio Scriptorium
✦   LIBER   ✦

HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription

✍ Scribed by Partha Mitra; Ronglin Xie; J. Wade Harper; Janet L. Stein; Gary S. Stein; Andre J. van Wijnen

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
289 KB
Volume
101
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cell cycle progression beyond the G~1~/S phase transition requires the activation of a transcription complex containing histone nuclear factor P (HiNF‐P) and nuclear protein mapped to ataxia telangiectasia (p220^NPAT^) in response to cyclin dependent kinase 2 (CDK2)/cyclin E signaling. We show here that the potent co‐activating properties of HiNF‐P/p220^NPAT^ on the histone H4 gene promoter, which are evident in the majority of human cell types, are sporadically neutralized in distinct somatic cell lines. In cells where HiNF‐P and p220^NPAT^ do not activate the H4 gene promoter, HiNF‐P instead represses transcription. Our data suggest that the cell type specific expression of the cyclin‐dependent kinase inhibitory (CKI) protein p57^KIP2^ inhibits the HiNF‐P dependent activation of the histone H4 promoter. We propose that, analogous to E2F proteins and other cell cycle regulatory proteins, HiNF‐P is a bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context. J. Cell. Biochem. 101: 181–191, 2007. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

CDK inhibitors selectively diminish cell
CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P
✍ Partha Mitra; Prachi N. Ghule; Margaretha van der Deen; Ricardo Medina; Rong-lin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 593 KB

## Abstract Cell cycle progression into S phase requires the induction of histone gene expression to package newly synthesized DNA as chromatin. Cyclin E stimulation of CDK2 at the Restriction point late in G1 controls both histone gene expression by the p220^NPAT^/HiNF‐P pathway and initiation of

The interactome of the histone gene regu
The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing
✍ Angela Miele; Ricardo Medina; Andre J. van Wijnen; Gary S. Stein; Janet L. Stein 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 332 KB

## Abstract HiNF‐P is a recently identified histone H4 subtype specific transcriptional regulator that associates with the conserved cell cycle control element in the proximal promoter regions of histone H4 genes. HiNF‐P interacts with the global histone gene regulator and direct cyclin E/CDK2 subs

HiNF-D (CDP-cut/CDC2/cyclin A/pRB-comple
HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition
✍ Farah Aziz; André J. Van Wijnen; Janet L. Stein; Gary S. Stein 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 2 views

Cell cycle control of histone H4 gene transcription is mediated by the multipartite promoter domain H4-Site II, which supports transcriptional activation at the G1/S phase transition and modulates basal H4 gene transcription. Proliferation-specific transcription is determined by the integrated activ

Tumor suppressor pRB functions as a co-r
Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription
✍ Sunita Gupta; Mai X. Luong; Sylvia A. Bleuming; Angela Miele; Michael Luong; Dan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 602 KB

## Abstract The CCAAT displacement protein (CDP‐cut/CUTL1/cux) performs a key proliferation‐related function as the DNA binding subunit of the cell cycle controlled HiNF‐D complex. HiNF‐D interacts with all five classes (H1, H2A, H2B, H3, and H4) of the cell‐cycle dependent histone genes, which are

TRANSCRIPTIONAL CONTROL OF CELL CYCLE PR
TRANSCRIPTIONAL CONTROL OF CELL CYCLE PROGRESSION: THE HISTONE GENE IS A PARADIGM FOR THE G1/S PHASE AND PROLIFERATION/DIFFERENTIATION TRANSITIONS
✍ GARY S. STEIN; JANET L. STEIN; ANDRÉ J. VAN WIJNEN; JANE B. LIAN 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 180 KB

The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initi