✦ LIBER ✦

TRANSCRIPTIONAL CONTROL OF CELL CYCLE PROGRESSION: THE HISTONE GENE IS A PARADIGM FOR THE G1/S PHASE AND PROLIFERATION/DIFFERENTIATION TRANSITIONS

✍ Scribed by GARY S. STEIN; JANET L. STEIN; ANDRÉ J. VAN WIJNEN; JANE B. LIAN

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 180 KB
Volume: 20
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1996.0007

No coin nor oath required. For personal study only.

✦ Synopsis

The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein-DNA and protein-protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.

📜 SIMILAR VOLUMES

HiNF-D (CDP-cut/CDC2/cyclin A/pRB-comple

HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition

✍ Farah Aziz; André J. Van Wijnen; Janet L. Stein; Gary S. Stein 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 2 views

Cell cycle control of histone H4 gene transcription is mediated by the multipartite promoter domain H4-Site II, which supports transcriptional activation at the G1/S phase transition and modulates basal H4 gene transcription. Proliferation-specific transcription is determined by the integrated activ