๐”– Bobbio Scriptorium
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Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression

โœ Scribed by Hiyama, Hirofumi; Iavarone, Antonio; LaBaer, Joshua; Reeves, Steven A

Book ID
110060696
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
846 KB
Volume
14
Category
Article
ISSN
0950-9232

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Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and