Secalonic acid D blocks embryonic palatal mesenchymal cell-cycle by altering the activity of CDK2 and the expression of p21 and cyclin E

TP53 alterations in relation to the cell

TP53 alterations in relation to the cell cycle-associated proteins p21, cyclin D1, CDK4, RB, MDM2, and EGFR in cancers of the uterine corpus

✍ Skomedal, Hanne; Kristensen, Gunnar B.; Nesland, Jahn M.; B�rresen-Dale, Anne-Li 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB 👁 2 views

In the present study, TP53 alterations have been analysed and compared with the expression of the proteins p21, cyclin D1, cdk4, RB, EGFR, and MDM2 in 53 cancers of the uterine corpus. TP53 gene mutations analysed by CDGE/DGGE and direct sequencing showed a TP53 gene mutation in 18 per cent of the c