β Scribed by Brothman, Arthur R.; Maxwell, Teresa M.; Cui, Jiang; Deubler, Debra A.; Zhu, Xiao Lin
No coin nor oath required. For personal study only.
BACKGROUND. Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors. METHODS. These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported. RESULTS. Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent. CONCLUSIONS. A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.
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## Abstract Cytogenetic and molecular studies have suggested that deletion or rearrangement of sequences that map to the short arm of chromosome 8 may be permissive for tumorigenesis in several organ systems, and in human prostate tumors in particular. In this study, we hypothesized that genes dele