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Haploinsufficiency and reduced expression of genes localized to the 8p chromosomal region in human prostate tumors

✍ Scribed by Hassan Chaib; James W MacDonald; Robert L Vessella; Joseph G Washburn; Janna E Quinn; Austin Odman; Mark A Rubin; Jill A Macoska

Book ID
118645076
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
89 KB
Volume
2
Category
Article
ISSN
1569-9056

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Haploinsufficiency and reduced expressio
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## Abstract Cytogenetic and molecular studies have suggested that deletion or rearrangement of sequences that map to the short arm of chromosome 8 may be permissive for tumorigenesis in several organ systems, and in human prostate tumors in particular. In this study, we hypothesized that genes dele

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Localization of genes encoding apolipoproteins CI, CII, and E to the p13β†’cen region of human chromosome 19
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The genes encoding apolipoproteins CI, CII, and E have been previously localized to chromosome 19. By use of rodent-human hybrid cell lines containing translocations of chromosome 19 we have now mapped these three genes to the region 19p13-19q13 and most probably 19p13-19cen. The clustering of APOC1