Chromosomal abnormalities and microsatellite instability in sporadic endometrial cancer
โ Scribed by R Muresu; M.C Sini; A Cossu; S Tore; P Baldinu; A Manca; M Pisano; C Loddo; S Dessole; A Pintus; F Tanda; G Palmieri
- Book ID
- 117658999
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 199 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0959-8049
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Sporadic cancers and familial breast cancers are characterized by an increase in genetic instability. Little is known about whether mismatch repair defects accompany this genetic instability. We investigated invasive and/or in situ breast cancers from 30 women with deleterious BRCA1/2 mutations and
Human breast-cancer specimens from 100 patients were analyzed for microsatellite instability (referred to as replication error; RER) at I 2 genomic loci on 7 chromosomes, and results were correlated with clinicopathologic characteristics. In 42 of I00 breast-cancer patients, we investigated whether