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Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer

✍ Scribed by Leopoldo Sarli; Lorena Bottarelli; Cinzia Azzoni; Nicoletta Campanini; Gabriella Di Cola; Giovanni Bader; Domenico Iusco; Carlo Salvemini; Giuseppe Caruso; Enrico Donadei; Silvia Pizzi; Tiziana D'Adda; Costi Renato; Luigi Roncoroni; Cesare Bordi

Book ID
116428166
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
185 KB
Volume
40
Category
Article
ISSN
0959-8049

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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC

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## BACKGROUND. Widespread microsatellite instability (MSI) occurs in nearly 15% of sporadic colorectal cancers. Large bowel carcinomas with high-frequency MSI (MSI-H) (instability at Υ† 30% of microsatellite loci) are believed to display distinctive pathologic features and to behave less aggressive