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Chromosomal aberrations, sister chromatid exchanges, and urinary thioethers in nurses handling antineoplastic drugs

✍ Scribed by Dr. Franco Sarto; Andrea Trevisan; Rosella Tomanin; Arianna Canova; Mario Fiorentino

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
382 KB
Volume
18
Category
Article
ISSN
0271-3586

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✦ Synopsis

Abstract

In this study we examined the structural chromosomal aberrations (CA) and sister chromatid exchanges (SCE) of 12 nurses handling moderate quantities of antineoplastic drugs. Urinary thioethers were also measured to assess the potential exposure to alkyl‐ating drugs. Two control groups with similar mean age and smoking habits and working in the same hospital were also studied: 1) control clerks and 2) control nurses. Our study did not show any clear increase of chromosomal damage in exposed nurses as compared to controls. However, CA in control nurses were significantly increased (p = 0.05) with respect to control clerks. The results of baseline urinary excretion of thioethers were statistically higher (p < 0.02) in exposed subjects than in control clerks.

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