Chromogranins: Functional and Clinical Aspects

✍ Scribed by Karen B. Helle (auth.), Karen B. Helle, Dominique Aunis (eds.)

• Publisher: Springer US
• Year: 2002
• Tongue: English
• Leaves: 430
• Series: Advances in Experimental Medicine and Biology 482
• Edition: 1
• Category: Library

✦ Synopsis

Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With.
This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.

✦ Table of Contents

The Chromogranins....Pages 3-20
Chromogranins: Current Concepts....Pages 21-38
Signal-Mediated Sorting of Chromogranins to Secretory Granules....Pages 41-52
The Condensed Matrix of Mature Chromaffin Granules....Pages 55-67
Functional Role of Chromogranins....Pages 69-81
Inositol 1,4,5-Trisphosphate Receptor and Chromogranins A and B in Secretory Granules....Pages 83-94
Regulation of Chromogranin a Transcription and Catecholamine Secretion by the Neuropeptide Pacap....Pages 97-111
Neuroendocrine Cell-Specific Expression and Regulation of the Human Secretogranin II Gene....Pages 113-123
Characterization of Chromogranins in the Frog Rana ridibunda ....Pages 125-136
Expression of Equine Chromogranin A....Pages 137-142
Salivary Secretion of Chromogranin A Control by Autonomic Nervous System ....Pages 143-151
Proteolytic Processing of Chromogranins....Pages 155-166
Endothelial Handling of Chromogranin A....Pages 167-178
Tissue Plasminogen Activator and Chromaffin Cell Function....Pages 179-192
Chromogranin A Immunoreactivity in Neuroendocrine Cells in the Human Gastrointestinal Tract and Pancreas....Pages 193-203
Chromogranin A and Its Derived Peptides in the Rat and Procine Gastro-Entero-Pancreatic System....Pages 205-213
Regulation of Parathyroid Secretion....Pages 217-223
Vasostatins....Pages 225-238
Vasostatins....Pages 239-246
Pancreastatin....Pages 247-262
The Novel Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A 344–364 )....Pages 263-277
Secretoneurin — A Novel Link Between The Nervous and the Immune System....Pages 279-290
Chromogranin A Induces a Neurotoxic Phenotype in Brain Microglial Cells....Pages 291-298
Antibacterial and Antifungal Peptides Derived from Chromogranins and Proenkephalin-A....Pages 299-315
Measurements of Chromogranins and Chromogranin-Related Peptides by Immunological Methods....Pages 319-327
Chromogranins as Diagnostic and Prognostic Markers in Neuroendocrine Tumours....Pages 329-337
Assessment of Chromogranin a Using Two-Site Immunoassay....Pages 339-350
Chromogranin A and Tumor Necrosis Factor-α (TNF) in Chronic Heart Failure....Pages 351-359
Chromogranin A (CGA) and the Enterochromaffin-Like (ECL) Cell....Pages 361-367
Chromogranins in Non-Endocrine Tumours....Pages 369-373
Chromogranin A in Human Disease....Pages 377-388
A Physiological Role for the Granins as Prohormones for Homeostatically Important Regulatory Peptides?....Pages 389-397

✦ Subjects

Neurosciences; Oncology; Cardiology; Pharmacology/Toxicology; Biochemistry, general