GABA and Sleep: Molecular, Functional and Clinical Aspects

✍ Scribed by Hanns Möhler (auth.), Jaime M. Monti, Seithikurippu Ratnas Pandi-Perumal, Hanns Möhler (eds.)

• Publisher: Springer Basel
• Year: 2010
• Tongue: English
• Leaves: 514
• Edition: 1
• Category: Library

✦ Synopsis

GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. This book brings together many of the world’s leading investigators to discuss current and anticipated developments in the areas of geriatric sleep medicine and provides a comprehensive examination of current principles and practice in this field. It is divided into three main sections: Section I: Basic Physiology and Pharmacology Section II: Sleep Science and Circuitry Section III: Neurotherapeutics The areas covered include findings from research investigations various aspects of GABAergic systems and the regulation of sleep. The book is suitable for basic and clinical neuropharmacologists, sleep researchers, psychiatrists, sleep disorders specialists, clinicians, medical students, and all professionals interested in the interdisciplinary areas of sleep and neuropharmacology.

✦ Table of Contents

Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Physiology and Pharmacology of the GABA System: Focus on GABA Receptors....Pages 3-23
Development of Subtype-Selective GABA A Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy....Pages 25-72
Distribution of GABA A Receptor Subunits in the Human Brain....Pages 73-93
Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics....Pages 95-118
Front Matter....Pages 119-119
Sleep and Its Modulation by Substances That Affect GABA A Receptor Function....Pages 121-146
Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System....Pages 147-168
Function of GABA B and ρ-Containing GABA A Receptors (GABA C Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes....Pages 169-188
Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness....Pages 189-198
GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation....Pages 199-212
Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT–PPT) in the Promotion of REM Sleep....Pages 213-231
GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site – in the Modulation of Sleep–Wake States....Pages 233-252
The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep....Pages 253-277
Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms....Pages 279-301
GABA Involvement in the Circadian Regulation of Sleep....Pages 303-321
Front Matter....Pages 323-323
Pathophysiology of Sleep Disorders....Pages 325-361
Insomnia: Differential Diagnosis and Current Treatment Approach....Pages 363-381
Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients....Pages 383-411
Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia....Pages 413-451
Indiplon....Pages 453-464
Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia....Pages 465-480
Back Matter....Pages 481-486

✦ Subjects

Human Physiology