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Chromatin signaling in DNA damage checkpoint response

✍ Scribed by S.J. Kron; C.C. Nnakwe; E.V. Efimova; C. Chakraborty; R.R. Weichselbaum; J. Côté

Book ID: 119598644
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 85 KB
Volume: 6
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(08)71415-0

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The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (progra