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New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

✍ Scribed by Dai, Y.; Grant, S.

Book ID
115439653
Publisher
American Association for Cancer Research
Year
2010
Tongue
English
Weight
381 KB
Volume
16
Category
Article
ISSN
1078-0432

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## Abstract In response to certain types of DNA damage, ataxia telangiectasia and rad3‐related (ATR) phosphorylates checkpoint kinase 1 (CHEK1) resulting in cell cycle arrest and subsequent DNA repair. __ATR__ and __CHEK1__ contain mononucleotide microsatellite repeat regions, which are mutational