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Chromatin remodeling in Embryonic stem cells: Regulating the balance between pluripotency and differentiation

✍ Scribed by Bridget Keenen; Ivana L. de la Serna

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
171 KB
Volume
219
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Embryonic stem cells have an unlimited potential for self‐renewal yet are pluripotent, capable of differentiating into three different germ layers and ultimately into multiple cell lineages. Key pluripotency specific factors maintain an undifferentiated ES cell phenotype while lineage specific factors work in opposition to promote cell specialization. In addition to these important transcriptional regulators, epigenetic modifiers play a defining role in regulating the balance between pluripotency and differentiation by promoting changes in chromatin structure. J. Cell. Physiol. 219: 1–7, 2009. Β© 2008 Wiley‐Liss, Inc.

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