𝔖 Bobbio Scriptorium
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Chromatin organization at meiosis

✍ Scribed by Peter B. Møens; Ronald E. Pearlman

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
476 KB
Volume
9
Category
Article
ISSN
0265-9247

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✦ Synopsis

From 1956, when the complex ultrastructure of meiotic chromosomes was discovered,' until 1985, when the isolation of meiotic chromosome cores was reported, knowledge of the molecular structure of the meiotic chromosome was at best a dream. The dissection of meiotic chromosome structures has become a realistic challenge through the arrival of isolated symptonemal complexes (SCs), monoclonal and polyclonal antibodies against SCs, the possibility for screening expression libraries for genes that encode SC proteins, the isolation of SC-associated DNA, and the development of techniques for the in situ recognition of DNA sequences in the context of the meiotic chromosome structure.

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