๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Chromatin organization and virus gene expression

โœ Scribed by Paul M. Lieberman

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
243 KB
Volume
216
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Many viruses introduce DNA into the hostโ€cell nucleus, where they must either embrace or confront chromatin factors as a support or obstacle to completion of their life cycle. Compared to the eukaryotic cell, viruses have compact and rapidly evolving genomes. Despite their smaller size, viruses have complex life cycles that involve dynamic changes in DNA structure. Nuclear entry, transcription, replication, genome stabilization, and virion packaging involve complex changes in chromosome organization and structure. Chromatin dynamics and epigenetic modifications play major roles in viral and host chromosome biology. In some cases, viruses may use novel or viralโ€specific epigenetic modifying activities, which may reflect variant pathways that distinguish their behavior from the bulk of the cellular chromosome. This review examines several recent discoveries that highlight the role of chromatin dynamics in the life cycle of DNA viruses. J. Cell. Physiol. 216: 295โ€“302, 2008. ยฉ 2008 Wileyโ€Liss, Inc.

๐Ÿ“œ SIMILAR VOLUMES

Dynamic chromatin: The regulatory domain
Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci
โœ Constanze Bonifer; Andreas Hecht; Harald Saueressig; Diana M. Winter; Albrecht E ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 852 KB

It is hypothesized that nuclear DNA is organized in topologically constrained loop domains defining basic units of higher order chromatin structure. Our studies are performed in order to investigate the functional relevance of this structural subdivision of eukaryotic chromatin for the control of ge

Chromatin organization at meiosis
Chromatin organization at meiosis
โœ Peter B. Mรธens; Ronald E. Pearlman ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 476 KB

From 1956, when the complex ultrastructure of meiotic chromosomes was discovered,' until 1985, when the isolation of meiotic chromosome cores was reported, knowledge of the molecular structure of the meiotic chromosome was at best a dream. The dissection of meiotic chromosome structures has become a

Does CTCF mediate between nuclear organi
Does CTCF mediate between nuclear organization and gene expression?
โœ Rolf Ohlsson; Victor Lobanenkov; Elena Klenova ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 530 KB

## Abstract The multifunctional zincโ€finger protein CCCTCโ€binding factor (CTCF) is a very strong candidate for the role of coordinating the expression level of coding sequences with their threeโ€dimensional position in the nucleus, apparently responding to a โ€œcodeโ€ in the DNA itself. Dynamic interac

Vaccinia virus vectors for gene expressi
Vaccinia virus vectors for gene expression
โœ Geoffrey L. Smith ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 406 KB

Improvements to vaccinia virus expression vectors continue to be made. In particular, there are new methods for the construction of recombinant viruses, ways of increasing the level of gene expression, and vectors that allow the inducible expression of selected genes.

Organization and expression of the human
Organization and expression of the human myelin basic protein gene
โœ Dr. J. Kamholz; J. Toffenetti; R. A. Lazzarini ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 891 KB

The human brain contains four isoforms of myelin basic protein (MBP), previously identified by cDNA cloning. We have now isolated and characterized genomic clones encoding the human MBP gene. The gene is 45 kb in extent and consists of seven exons. Alternative splicing of the primary MBP transcript