## Abstract Recent studies have shown that ethyl pyruvate (EP) acts as an antiβinflammatory molecule in several cell lines including RAW264.7 macrophages. However, the potential therapeutic value of EP for the treatment of the pathologic brain has not been investigated fully. In the present study,
Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse
β Scribed by Kyung-Jin Jang; Kyou-Heung Lee; Sang-Lin Kim; Dong-Young Choi; Beom-Kyu Park; Doo-Hyun Im; Yong-Joon Cho; Wang-Kee Jhoo; Hyoung-Chun Kim
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 741 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0253-6269
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π SIMILAR VOLUMES
Seizure activity induced by kainic acid (KA) and subsequent neuronal death are thought to be associated with an increase in cytoplasmic free calcium ([Ca2+li) and can be prevented by N-methyl-D-aspartate (NMDA) antagonists. In addition to influx through receptor operated Ca2+ channels the increase i
## Abstract Kainic acid (KA)βinduced status epilepticus (SE) is a wellβcharacterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe