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In vivoEvaluation of the Effect of Zonisamide on the Hippocampal Redox State During Kainic Acid-Induced Seizure Status in Rats

✍ Scribed by Yuto Ueda; Taku Doi; Jun Tokumaru; Akira Nakajima; Keiko Nagatomo


Publisher
Springer
Year
2005
Tongue
English
Weight
219 KB
Volume
30
Category
Article
ISSN
0364-3190

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## Abstract Kainic acid (KA)‐induced status epilepticus (SE) is a well‐characterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe