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Kinetics of drug action in disease states XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats

โœ Scribed by Masato Yasuhara; Gerhard Levy


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
252 KB
Volume
77
Category
Article
ISSN
0022-3549

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Kinetics of drug action in disease state
โœ Masafumi Hisaoka; Gerhard Levy ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 486 KB ๐Ÿ‘ 1 views

The purpose of this investigation was to determine if the reported prolongation of barbiturate-and ethanol-induced sleeping times by nicotine in rodents are pharmacodynamic or pharmacokinetic interactions. Adult female rats were pretreated with nicotine, either 0.5 or 1.5 mg/kg ip acutely or 0.5 mg/