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Chondroitin Sulfate Proteoglycans Are Associated with the Lesions of Alzheimer's Disease

✍ Scribed by David A. DeWitt; Jerry Silver; David R. Canning; George Perry


Book ID
115605984
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
442 KB
Volume
121
Category
Article
ISSN
0014-4886

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## Abstract Accumulating evidence indicates that the heparan‐sulfate‐proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to la