Chondrocyte number and proteoglycan synthesis in the ageing and osteoarthritic human articular cartilage
β Scribed by K Bobacz, A Soleiman, L Erlacher, J Smolen, WB Graninger
- Book ID
- 120708004
- Publisher
- BioMed Central
- Year
- 2003
- Tongue
- English
- Weight
- 595 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar724
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## Abstract The study was designed to determine the contents and distributions of the proteoglycans decorin and biglycan in adult human femoral condylar cartilage and whether these may change in osteoarthritis. New radioimmunoassays were established using peptides representing the aminoβterminal 21
Proteases have been postulated to account for the progressive disappearance of matrix proteoglycans in osteoarthritic (OA) cartilage. The digestion of endogenous proteoglycans by neutral proteases in human OA cartilage homogenates has been measured and compared with that of normal age-matched contro