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Choline levels in plasma of myasthenia gravis patients and normal individuals

✍ Scribed by Cathy Stein Ms; Walter Moore; Daniel Weinreich; Richard F. Mayer

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 219 KB
Volume: 4
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410040318

No coin nor oath required. For personal study only.

✦ Synopsis

Although the role of choline in blood is not well understood, several recent studies have attempted to link blood choline levels with diseases involving central cholinergic dysfunction [ l , 4, 61. It is well known that myasthenia gravis is a disease involving the neuromuscular junction in man, and it has been reported that a defect in acetylcholine synthesis might account for the clinical weakness [2]. In the present investigation, plasma choline levels of patients with myasthenia gravis were compared with those of normal individuals to determine whether this disease is associated with differences in free plasma choline concentrations.

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