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Chloroform-Induced Cytolethality in Freshly Isolated Male B6C3F1Mouse and F-344 Rat Hepatocytes

✍ Scribed by Pierre Ammann; Carmen L. Laethem; Gregory L. Kedderis


Book ID
112266591
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
121 KB
Volume
149
Category
Article
ISSN
0041-008X

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Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related incr