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Metabolism and Disposition of Phenolphthalein in Male and Female F344 Rats and B6C3F1 Mice

โœ Scribed by Robert J. Griffin; Veronica B. Godfrey; Leo T. Burka


Book ID
112268729
Publisher
Oxford University Press
Year
1998
Tongue
English
Weight
134 KB
Volume
42
Category
Article
ISSN
1096-6080

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Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related incr