Chlordecone potentiation of carbon tetrachloride toxicity: A metabonomic-based mechanistic study
โ Scribed by D. De Luca; V. Tagliatti; R. Conotte; J. Colet
- Book ID
- 116924438
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 91 KB
- Volume
- 205
- Category
- Article
- ISSN
- 0378-4274
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Our previous studies indicated the involvement of some unidentified mechanisms, apart from the bioactivation phenomenon, in chlordecone (CDkpotentiated CCI, hepatotoxicity and lethality. Recent studies revealed that hepatocellular regeneration is suppressed in CD + CCI, toxicity. The present work is
Chlordecone greatly potentiates carbon tetrachloride (CC14) hepatotoxicity. In order to quantitate the degree of this potentiation, the effects of a range of doses of C C 4 on two microsomal enzymatic functions and liver enzyme release were examined in chlordecone-treated and control rats. Male Spra