Our previous studies indicated the involvement of some unidentified mechanisms, apart from the bioactivation phenomenon, in chlordecone (CDkpotentiated CCI, hepatotoxicity and lethality. Recent studies revealed that hepatocellular regeneration is suppressed in CD + CCI, toxicity. The present work is
Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: A morphometric and biochemical study
โ Scribed by Virginia G. Lockard; Harihara M. Mehendale; Robert M. O'Neal
- Book ID
- 113147253
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 685 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0014-4800
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Induction of P450IIE1 by pyridine was compared with that by ethanol, and the resulting potentiation of the pneumotoxicity and hepatotoxicity following carbon tetrachloride inhalation by pyridine was examined. Rats were treated with ethanol as either a 10% solution in the drinking water or as a daily
Chlordecone greatly potentiates carbon tetrachloride (CC14) hepatotoxicity. In order to quantitate the degree of this potentiation, the effects of a range of doses of C C 4 on two microsomal enzymatic functions and liver enzyme release were examined in chlordecone-treated and control rats. Male Spra