The preparation of methyl 3-O-tert-butyldiphenylsilyl-2,4-dideoxy-B-D-erythrohexopyranoside, a key chiral intermediate for mevinic acids, and its elaboration into four mevinate analogues are described.
Chiral synthons for the elaboration of mevinic acid analogues
โ Scribed by Frank Bennett; David W. Knight; Garry Fenton
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 248 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The reaction of the allylic carbonate 2 with organocopper derivatives is the key step of a new strategy for the synthesis of mevinic acid analogues.
Stereoselective synthesis of a 1,2,3,4-tetrasubstituted cyclohexane 23, intermediate towards Karanewsky's monocyclic Compactin analogue 3, has been performed starting from levoglucosan 4.
A simple synthesis of various 6-amino-2-substitutcd hexanoic acids has been developed starting from lysine via the triflate of 6-amino-2-hydroxy hexanoic acid. The same reactions have also been successfully applied starting from the lysyl-proline sequence. The lysine analogues have been introduced i