## Abstract The chemical resolution of γ,γ′‐di‐__t__‐butyl DL‐__N__‐benzyloxycarbonyl‐γ‐carboxy‐glutamate is described in detail (preliminary account see [1]). The D (−)‐derivative was obtained as a crystalline quinine salt, and the L (+)‐derivative as a crystalline salt with (−)‐ephedrine in yield
Chiral synthesis of L-γ-carboxyglutamic acid (L-Gla)
✍ Scribed by Marla A. Schuerman; Kathryn I. Keverline; Richard G. Hiskey
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 191 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The purpose of this communication is to describe the preparation and some properties of the first two synthetic peptides containing D‐ and L‐γ‐carboxyglutamic acid. Use was made of __N__‐protected γ,γ′‐di‐__t__‐butyl‐γ‐carboxyglutamic acids (D, L, and DL) described earlier [1 a]. Prelim
A stereo-and enantio-specific synthesis of the natural1 occurring cis-%hydroxy-(L)-pipecolic acid (3) is described, starting from Z-(L -glutamic the key step involves c chsation of a Y, to trans-%hydroxy-(L -pipecolic acl 3 3 rotected chlorohydrin, and also gives access acid, .