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Chiral Sulfoxides in Asymmetric Synthesis: Enantioselective Synthesis of the Lactonic Moiety of (+)-Compactin and (+)-Mevinolin. Application to a Compactin Analog

โœ Scribed by Solladie, Guy; Bauder, Claude; Rossi, Leucio

Book ID
126451520
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
547 KB
Volume
60
Category
Article
ISSN
0022-3263

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The stereoselective Michael addition of alcohols dihydro-2tj-pyran-2-one afforded high yields of a key chiral portion of compactin and mevinolin. to 6-tosyloxymethyl-5,6synthon for the lactone Compactin (1) mevinolin (2) and related compounds have been cholesterol levels in animal models and man and