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Chiral reagents for the determination of enantiomeric excess and absolute configuration using NMR spectroscopy

✍ Scribed by Thomas J. Wenzel; James D. Wilcox


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
257 KB
Volume
15
Category
Article
ISSN
0899-0042

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## Abstract The enantiomeric purities of disubstituted β‐lactams were determined by ^1^H and ^13^C NMR spectroscopy using tris[3‐(trifluoromethylhydroxymethylene)‐d‐camphorato]europium(III), Eu(tfc)~3~, as a chiral shift reagent. Using a [Eu(tfc)~3~]/[lactam] ratio of 0.5, most of the resonances we