Use of shift reagent with mtpa derivatives in 19F NMR spectroscopy: III. Determination of absolute configuration and enantiomeric purity of secondary alcohols

✍ Scribed by A. J. De Van Wal; E. M. Merckx; G. L. Lemière; T. A. van Osselaer; J. A. Lepoivre; F. C. Alderweireldt

• Publisher: Wiley (John Wiley & Sons)
• Year: 2010
• Weight: 306 KB
• Volume: 87
• Category: Article
• ISSN: 0037-9646
• DOI: 10.1002/bscb.19780870707

✦ Synopsis

The LIS values produced by Eu(fodJ3 for the CF3-19F NMR signals of the MlTA e s t e r s of different stereoisomeric secondary alcohols have been measured. The applicability o f these values for assigning the absolute configuration of the alcohols has been studied. The advantages of t h i s method over the corresponding 1H NMR method o f Yamaguchi and the limits of both have been investigated. A new model of the Eu(fod)3/MTPA ester complex i s given.