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Chiral Phosphaalkene−Oxazoline Ligands for the Palladium-Catalyzed Asymmetric Allylic Alkylation

✍ Scribed by Dugal-Tessier, Julien; Dake, Gregory R.; Gates, Derek P.


Book ID
125899143
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
385 KB
Volume
12
Category
Article
ISSN
1523-7060

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Novel chiral phosphine–oxazinane ligands
✍ Takashi Mino; Sosuke Hata; Kouji Ohtaka; Masami Sakamoto; Tsutomu Fujita 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 81 KB

Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (8a) with a dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of novel chiral phosphine-oxazinane ligands such as 5b in good yields with good enantioselectivities (up to 95% ee).