Chiral nitrogen compounds as new modifiers for the enantioselective hydrogenation of ethyl pyruvate
✍ Scribed by B. Minder; M. Schürch; T. Mallat; A. Baiker
- Book ID
- 112413061
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 439 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1011-372X
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📜 SIMILAR VOLUMES
New chiral and enantiopure erythro and threo 1,2-amino-alcohols 4a and 4b have been shown to accelerate the heterogeneous catalytic hydrogenation of ethyl pyruvate as much as cinchonidine does (with 77-100% conversion within 2 h). A diastereo dependence of the enantioselectivity is clearly observed
A vinca-type synthetic alkaloid: ( -)-dihydrovinpocetine functions as a chiral auxiliary in the enantioselective hydrogenation of the C=O group of ethyl pyruvate. Various catalysts, supports, solvents have been screened. The effect of modifier's concentration, acetic acid additive and of combined mo