A new class of chiral modifiers for the enantioselective hydrogenation of α-ketoesters with PtAl2O3
✍ Scribed by Keith E Simons; Guozhi Wang; Thomas Heinz; Thomas Giger; Tamas Mallat; Andreas Pfaltz; Alfons Baiker
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 660 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
New chiral and enantiopure erythro and threo 1,2-amino-alcohols 4a and 4b have been shown to accelerate the heterogeneous catalytic hydrogenation of ethyl pyruvate as much as cinchonidine does (with 77-100% conversion within 2 h). A diastereo dependence of the enantioselectivity is clearly observed
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The enantioselective hydrogenations of ethyl pyruvate (EP), methyl benzoylformate (MBF), ketopantolactone (KPL) and pyruvaldehyde dimethylacetal (PADA) were studied on Pt-alumina catalyst modified by a new modifier namely ␣-isoquinine (␣-IQ) with rigid conformation and for comparison by quinine (Q)