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Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

✍ Scribed by Mitscher, Lester A.; Sharma, Padam N.; Chu, Daniel T. W.; Shen, Linus L.; Pernet, Andre G.


Book ID
126182933
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
534 KB
Volume
29
Category
Article
ISSN
0022-2623

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Synthesis and antibacterial activity of
✍ Jia-Yuh Sheu; Yeh-Long Chen; Kuo-Chang Fang; Tai-Chi Wang; Cherng-Chyi Tzeng; Ch 📂 Article 📅 1998 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 572 KB

## Abstract Alkylation of 6,7‐difluoro‐4‐hydroxyquinoline‐3‐carboxylic acid ethyl ester with substituted‐benzyl chlorides gave 1‐(substituted‐benzyl)‐6,7‐difluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid ethyl esters. Their treatment with piperazine or __N__‐methylpiperazine in pyridine yielded