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Synthesis and antibacterial activity of 6- and 7-[furyl-2]-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

✍ Scribed by R. G. Glushkov; E. V. Adamskaya; A. F. Oleinik; V. A. Silin; E. N. Padeiskaya; N. P. Solov'eva


Book ID
112397072
Publisher
Springer
Year
1986
Tongue
English
Weight
328 KB
Volume
20
Category
Article
ISSN
0091-150X

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✍ Jia-Yuh Sheu; Yeh-Long Chen; Kuo-Chang Fang; Tai-Chi Wang; Cherng-Chyi Tzeng; Ch 📂 Article 📅 1998 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 572 KB

## Abstract Alkylation of 6,7‐difluoro‐4‐hydroxyquinoline‐3‐carboxylic acid ethyl ester with substituted‐benzyl chlorides gave 1‐(substituted‐benzyl)‐6,7‐difluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid ethyl esters. Their treatment with piperazine or __N__‐methylpiperazine in pyridine yielded