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Synthesis and antibacterial activity of some 7-substituted 1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acids: Ethers, secondary amines and sulfides as c-7 substituents

✍ Scribed by Carl B. Ziegler Jr.; William V. Curran; Nydia A. Kuck; Sonja M. Harris; Yang-I. Lin


Book ID
112129355
Publisher
Journal of Heterocyclic Chemistry
Year
1989
Tongue
English
Weight
278 KB
Volume
26
Category
Article
ISSN
0022-152X

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Synthesis and antibacterial activity of
✍ Jia-Yuh Sheu; Yeh-Long Chen; Kuo-Chang Fang; Tai-Chi Wang; Cherng-Chyi Tzeng; Ch 📂 Article 📅 1998 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 572 KB

## Abstract Alkylation of 6,7‐difluoro‐4‐hydroxyquinoline‐3‐carboxylic acid ethyl ester with substituted‐benzyl chlorides gave 1‐(substituted‐benzyl)‐6,7‐difluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid ethyl esters. Their treatment with piperazine or __N__‐methylpiperazine in pyridine yielded