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Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives

✍ Scribed by Zhiyi Yu; Guanying Shi; Qiu Sun; Hong Jin; Yun Teng; Ke Tao; Guoping Zhou; Wei Liu; Fang Wen; Taiping Hou


Book ID
108116291
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
830 KB
Volume
44
Category
Article
ISSN
0223-5234

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## Abstract 1‐Ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐7‐(1‐piperazinyl)‐ 3‐quinolinecarboxylic acid (__I__, AM‐715), a new potent antibacterial agent, was labelled with carbon‐14 at the C‐1 position of the N‐ethyl group for metabolic studies. The synthesis was achieved according to two reaction routes. Th