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Chiral catalysts for the enantioselective addition of organometallic reagents to aldehydes

✍ Scribed by E.J Corey; Francis J Hannon

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 284 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96695-4

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✦ Synopsis

A mechanistic model for the enantioselective addition of diethylzinc to benzaldehyde with chiral tridentate lithium complexes as catalysts correctly predicts the observed direction of enantioselectivity which occurs at levels of 8595% ee.

A recent paper from these laboratories described two rationally designed and effective chiral catalysts for the enantioselective conjugate addition of organocopper reagents to a$-en0nes.l Thus, the lithium salt derived 7. This research was assisted financially by a grant from the National Science Foundation.

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