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Chiral Acetylenic Sulfoxide in Enantioselective Synthesis of Yohimbine Alkaloid

✍ Scribed by Albert W.M. Lee*; W.H. Chan*; T. Mo

Book ID
104256884
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
369 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Through Michael additionlacid induced cyclization of secondzuy amine to chiral acetylenic sulfoxide followed by Putnmerer cyclization, an approach to the enantioselective syntheses of pentacyclic yohimbine alkaloids is presented. O 1997Elsevier ScienceLtd.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Chiral Acetylenic S
ChemInform Abstract: Chiral Acetylenic Sulfoxide in Enantioselective Synthesis of Yohimbine Alkaloid.
✍ A. W. M. LEE; W. H. CHAN; T. MO πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 27 KB

Chiral Acetylenic Sulfoxide in Enantioselective Synthesis of Yohimbine Alkaloid. -Michael addition of the secondary amine (I) to the chiral acetylenenic sulfoxide (II) followed by acid induced cyclization affords (III) as major product. It is a precursor of optically pure (IV), a known synthon of pe